arXiv:2603.13864v3 Announce Type: replace Abstract: Real-world backdoor attacks often require poisoned datasets to be stored and transmitted before they are used to compromise deep learning systems. In the era of big data, however, the inevitable use of lossy compression poses a fundamental challenge to invisible backdoor attacks. We observe that triggers embedded in RGB images can become ineffective once the images are lossily compressed into binary bitstreams, such as JPEG files, for storage and transmission. Consequently, poisoned data may lose their malicious functionality after compression, causing backdoor injection to fail. Prior compression-based attacks typically exploit compression artifacts as certain triggers to distinguish poisoned RGB samples from uncompressed benign ones, rather than addressing whether malicious information can survive a shared lossy storage-and-transmission pipeline. In this paper, we highlight the necessity of explicitly accounting for lossy compression in backdoor attacks. This requires attackers to ensure that transmitted binary bitstreams preserve malicious trigger information, such that effective triggers can be induced after decompression. Building on the region-of-interest (ROI) coding mechanism in image compression, we propose two poisoning strategies tailored to inevitable lossy compression. First, we introduce Universal Attack Reactivation, a general method that uses sample-specific ROI masks to reactivate trigger information in bitstreams for learned image compression (LIC). Second, we present Compression-Adapted Attack, a new attack strategy that employs customized ROI masks to encode trigger information into bitstreams and applies to both traditional codecs and LIC. Extensive experiments demonstrate the effectiveness of both strategies.