arXiv:2610.33437v1 Announce Type: new Abstract: Multi-trigger backdoor attacks, in which heterogeneous trigger mechanisms (e.g., patch, blend, warping, and the latent-domain Spy-Watermark) coexist within a single poisoned model, cannot be addressed by existing shortcut-based defenses that assume a single, static attack mechanism. Current multi-trigger remedies (BU+FT, BU+ANP, and BU+ABL) rely on backdoor unlearning, which incurs high training costs and loses effectiveness at low poisoning ratios. This paper proposes Combinatorial Lock, a training-free, reference-calibrated defense that reduces multi-trigger identification to a combinatorial problem over binary activation signatures. This formulation is the key novelty: it yields a multi-trigger defense that is training-free, trigger-oblivious, and directly implementable in hardware, since its decision rules can be evaluated with integer and logic operations. The framework combines anomaly-gated spectral scrubbing, which removes the malicious subspace only from inputs identified as anomalous, with a hash-compressed combinatorial signature verified by an ensemble of detection experts, including a compound-attack-aware expert for multi-trigger inputs. A joint threshold-shrinkage search identifies an operating point ($\tau$ at the 97.1st percentile, $\gamma = 0.78$) that reduces the attack success rate (ASR) to as low as 0.1% while preserving 97.8% clean accuracy. Evaluation on six models (ResNet18, VGG16, MobileNet, AlexNet, ViT-Small, ViT-Base) shows strong generalization: near-100% ASR drops to single digits across poisoning rates of 1-10% and 1-9 simultaneous triggers, with only gradual degradation in clean accuracy. ASIC and FPGA implementations confirm practicality, adding a consistent 19-20% latency overhead across all evaluated architectures and establishing Combinatorial Lock as a hardware-native approach to multi-trigger backdoor mitigation.