Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1
By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation.AI & ML
Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity
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Source：https://www.nature.com/articles/s41586-026-11087-1
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