arXiv:2610.07952v1 Announce Type: new Abstract: Navier-Stokes (NS) equations lose accuracy in the transition regime when the Knudsen number is large, while the Boltzmann equation provides an adequate kinetic description with a substantially higher computational cost. In this work, a data-driven generalized Navier-Stokes (GNS) model is proposed to extend the applicability of the NS equations to the transition regime. A new relationship between the non-equilibrium variables, such as the stress tensor and the heat flux, and the equilibrium variables, including the density, macroscopic velocity, and the temperature, together with the Knudsen number, is learned from the data formed by the numerical solution to the Boltzmann equation. The standard end-to-end learning is utilized to construct the loss function, based on which, a long-term end-to-end learning method is proposed for the loss function to reduce accumulated error and improve long-term predictive accuracy. Several numerical examples, including one-dimensional wave and Riemann problems as well as two-dimensional isentropic vortex and Taylor-Green vortex problems, are studied to validate the efficiency of this new GNS model.