arXiv:2610.10487v1 Announce Type: new Abstract: Large-scale scientific simulations generate substantial data volumes, making lossy compression essential for reducing storage and data movement costs. However, users configure compressors through numerical error bounds (EBs) while often evaluating results using quality metrics and end-to-end performance. Because the relationship between an EB and these outcomes varies across datasets and compressors, identifying a suitable configuration typically requires exhaustive search, which can be time-consuming and computationally demanding. We present LOCAA, an Large language model-based scientific lossy compression auto-tuning agent that performs compression-in-the-loop search using tool-integrated execution, compressor-aware guidance, and persistent memory. LOCAA supports user-defined objectives and constraints without requiring a specialized search strategy. We evaluate LOCAA across three scientific applications, five compressors, and three use cases: fixed-ratio compression, compression tuning under multiple quality constraints, and compression tuning under quality and time constraints. For fixed-ratio search across twelve fields from two applications, LOCAA requires 1.98x fewer evaluation trials than binary search and 5.03x fewer than FRaZ on average. For compression ratio maximization under joint Peak Signal-to-Noise Ratio (PSNR) and Structural Similarity Index Measure constraints across six fields from the Community Earth System Model application, LOCAA reduces the average evaluation trials from 61.5 using binary search to 17, corresponding to a 72.4% reduction. Persistent memory further reduces the average number of trials by 27.9% across multiple timesteps of the same field. These results demonstrate the potential of tool-augmented LLM agents to provide flexible and efficient compressor tuning across diverse scientific data and user-defined objectives.