arXiv:2610.21464v1 Announce Type: new Abstract: Retrieval-augmented generation (RAG) mitigates hallucinations and knowledge staleness in large language models using external knowledge. However, ingestion from public and third-party sources exposes RAG systems to poisoning attacks. Existing attacks are designed and evaluated under exact retrieval, where poisoned documents participate in global ranking. Deployment-scale systems instead rely on approximate nearest-neighbor (ANN) indexes such as hierarchical navigable small world (HNSW), where limited search budgets, graph-search reachability, and local benign-document competition invalidate this assumption and degrade existing attacks. We present a topology-aware topic-level poisoning attack against large-scale HNSW-RAG that generalizes to unseen topic queries. We organize poisoned documents into a Hub-Satellite structure: Satellites provide competitive entry points across semantic regions, while Hubs strengthen local cohesion and facilitate cascading retrieval. For generation, we propose an entity-claim promotion attack combining evidence anchoring and entity-claim coupling to promote the target entity via a target claim across different query regions. On 2M-document Wikipedia, our attack maintains over 72% retrieval success and reaches 31.29% attack success, substantially outperforming baselines; domain-specific experiments further support its effectiveness. Structural analyses show that the Hub-Satellite topology forms in HNSW, indicating that graph structure contributes to improved poisoned-document retrieval. Existing poisoning defenses cannot mitigate the attack, exposing graph-structural risks in HNSW-RAG systems.