arXiv:2610.23153v1 Announce Type: cross Abstract: Assessing whether qualitative responses collected from semi-structured questions are ready for a particular analysis goal is a persistent challenge. Manual qualitative analysis is interpretive and labor-intensive, while existing automated methods often lack a dataset-level perspective for deciding whether a response set supports a researcher-selected analytical lens. We introduce QuAD, a framework for quantitative pre-analysis assessment of qualitative response datasets. QuAD compares a reconstructed intrinsic cluster distribution reconstructed from responses with an extrinsic, researcher-defined analytical lens derived from metadata. QuAD is structured into a four-quadrant assessment whose metrics are read jointly, from lens-level relations to within-cluster variation, to provide fitness-for-purpose signals for revealing general patterns and unique insights. Because this assessment relies on lens-conditioned inter-response dissimilarity, we propose a content-aware multi-agent system with two-stage instruction generation and adaptive anchors to improve scoring consistency. We validate QuAD through controlled experiments on synthetic data, including robustness and baseline comparisons, and a real-world social survey case study. The case study shows how QuAD quantitatively assesses whether a selected analysis axis is promising and also surfaces representative or unusual responses for human interpretation.