Rare and common genetic variants shape single-cell immune gene expression

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-10721-2

Phase 1 of TenK10K takes single-cell RNA sequencing and matched whole-genome sequencing data from 1,925 individuals, enabling detection of associations for common and rare genetic variants, the latter of which have been uncharacterized in their impact on cell-specific gene expression.