arXiv:2610.21086v1 Announce Type: cross Abstract: Camera-to-robot pose estimation from a monocular image is significant for vision-based robot navigation and control. However, recovering 3D structural features from 2D observations remains a challenging task. Existing camera-to-robot pose estimation methods either rely on time-consuming iterative rendering or involve sophisticated 2D-3D registration which suffers from projection ambiguity, accumulated errors for distal joints and imbalanced learning for different joints. In this work, we propose RoPE-Flow, an end-to-end flow matching-based framework for camera-to-robot pose estimation. From the predicted 2D heatmaps, we propose a Keypoint-centered Feature Extractor to obtain positional features along with contextual representations from keypoints-centered multi-scale patches. Moreover, we introduce Graph-guided Condition Generator, which embeds a learnable adjacency map to generate condition for flow matching based on correlation among keypoints. Besides, we introduce Bone Length Loss and Ray-Depth Loss for topological consistency and scale stability, with joint-wise weighting to mitigate varied prediction difficulty across joints. The proposed method outperforms state-of-the-art methods for pose estimation across different types of robots with mutiple cameras. Besides, we establish a novel cross-scene benchmark to demonstrate the outstanding performance of RoPE-Flow on zero-shot cross-scene robot pose estimation. Meanwhile, animated visualizations are shown on the website: ropeflow.netlify.app