arXiv:2610.39476v2 Announce Type: replace-cross Abstract: Distributed quantum computing (DQC) connects multiple quantum processing units to overcome the scale limits of monolithic hardware. We introduce SeQUeNCe$.$DQC a new top-level module within the SeQUeNCe package that compiles monolithic circuits into topology-aware execution plans and coordinates their execution using SeQUeNCe's existing quantum-network modules and protocols. We validate SeQUeNCe$.$DQC by reproducing a two-node trapped-ion Grover experiment in simulation and comparing success probabilities with the reported 71% benchmark. We then evaluate how compiler strategy, topology, and memory capacity jointly govern distributed circuit execution time and success rate. In these experiments, our hybrid compilers successfully identified mixed TeleGate/TeleData execution plans that outperformed pure gate-teleportation strategies. By capturing the physical overhead of distributed quantum primitives, SeQUeNCe$.$DQC provides a rigorous platform for co-designing DQC software and hardware architectures.