arXiv:2610.12162v1 Announce Type: new Abstract: Random communication symbols allow integrated sensing and communications (ISAC) systems to exploit payload signals for sensing, but the resulting matched-filter response varies with the transmitted data. Existing statistical analyses of sensing with random orthogonal frequency division multiplexing (OFDM) waveforms have largely focused on delay and Doppler, while the spatial dimension introduced by multi-input multi-output (MIMO) arrays and precoding has received much less attention. This paper develops a three-dimensional ambiguity function (3D-AF) for random MIMO-OFDM waveforms over delay, Doppler, and angle domains. For point-target sensing, we express the 3D-AF as a quadratic form of the random communication symbols, with a deterministic matrix that captures the delay and Doppler shifts, the transmit and receive array responses, and the precoders on different subcarriers. Based on this representation, we derive a closed-form expression for the expected squared 3D-AF and show explicitly how the constellation fourth-order moment (or kurtosis) affects the ambiguity sidelobes. The same characterization yields expected integrated sidelobe level (EISL) and expected sidelobe level (ESL) metrics over mixed delay-Doppler-angle search domains. The framework is further extended to coherent multi-symbol processing with slow-time Doppler, leading to the corresponding fast-slow time (FST) approximation. These results provide a statistical characterization of the sensing ambiguity induced by random MIMO-OFDM communication signals in delay, Doppler, and angle.